{"id":3595,"date":"2023-05-11T15:24:18","date_gmt":"2023-05-11T08:24:18","guid":{"rendered":"https:\/\/loudhdtv.com\/is-dietary-cholesterol-in-a-relationship-with-cancer\/"},"modified":"2023-05-11T15:24:18","modified_gmt":"2023-05-11T08:24:18","slug":"is-dietary-cholesterol-in-a-relationship-with-cancer","status":"publish","type":"post","link":"https:\/\/loudhdtv.com\/?p=3595","title":{"rendered":"Is Dietary Cholesterol in a Relationship with Cancer?"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script><br \/>\n<\/p>\n<div>\n<p>What is the relationship between the consumption of eggs and other cholesterol-rich foods and cancers of the colon, breast, endometrium, pancreas, and throat?<\/p>\n<p>In 1969, a correlation analysis was <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/5366239\/\" target=\"_blank\" rel=\"noopener\">performed<\/a> by a Dr. Gregor\u2014no relation, and he spelled it wrong\u2014and his colleagues. They found a rather tight correlation between animal protein intake and intestinal cancer mortality. You can see a graph of these results at 0:15 in my video <strong><a href=\"https:\/\/nutritionfacts.org\/video\/friday-favorites-dietary-cholesterol-and-cancer\/\" target=\"_blank\" rel=\"noopener\">Friday Favorites: Dietary Cholesterol and Cancer<\/a><\/strong>. In the 1970s, this relationship was <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/4694388\/\" target=\"_blank\" rel=\"noopener\">extended<\/a> to include breast cancer, too, and animal fat was implicated as well. Animal protein and dietary cholesterol kind of <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/85993\/\" target=\"_blank\" rel=\"noopener\">travel<\/a> together in the same foods. So, it isn\u2019t surprising that \u201cthere <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/90870\/\" target=\"_blank\" rel=\"noopener\">is<\/a> significant correlation between high consumption of cholesterol-containing food items and the world-wide distribution of colon cancer.\u201d A \u201clarge and highly significant\u201d correlation <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/90870\/\" target=\"_blank\" rel=\"noopener\">exists<\/a>, even after controlling for other dietary factors, such as animal fat and fiber, \u201csupporting the possibility of a causal relationship between cholesterol intake and colon cancer.\u201d<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-91634\" src=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1.png 1920w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-960x540.png 960w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-1024x576.png 1024w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-768x432.png 768w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-1536x864.png 1536w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-480x270.png 480w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-1200x675.png 1200w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-720x405.png 720w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/03\/0-15-1-540x304.png 540w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\"\/><\/p>\n<p>So, is dietary cholesterol co-carcinogenic for human colon cancer? Researchers decided to try to find out by feeding some to rats. In one study, researchers <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/723955\/\" target=\"_blank\" rel=\"noopener\">injected<\/a> rats with a carcinogen, and the cholesterol-eating rats got tumors in half the time and they all died, whereas most of the rats in the cholesterol-free group survived. But \u201cthe relevance of animal data to the human situation is debatable.\u201d How would the cholesterol and cancer link even work?<\/p>\n<p>As humans, we don\u2019t need to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/85993\/\" target=\"_blank\" rel=\"noopener\">consume<\/a> any cholesterol, since our body makes all that it needs. When we do consume extra cholesterol, there\u2019s a limit to the amount our body can absorb. So, \u201cwhere does the excess go?\u201d Down to our colon. In this way, the cells lining our colon, where colon cancer arises, \u201care therefore constantly exposed to fecal cholesterol.\u201d Should a cancerous or precancerous polyp arise, might all of that extra cholesterol help it grow faster? Indeed, the amount of cholesterol we eat \u201ccould thus be a factor determining the rate of development, growth, or spread of such a tumor.\u201d Back in the 1970s, this was all just speculation, but the researchers realized that if it were true, that would be good news, since a low-cholesterol diet, cutting down on meat, dairy, eggs, and junk\u2014the only foods that really have cholesterol\u2014would be a \u201cfeasible, inexpensive, and without risk\u201d way to help prevent and treat colon cancer. So, what\u2019s the 40-year update?<\/p>\n<p>Country-by-country correlation can never do more than just inspire studies like this: \u201cthe largest nationwide population-based case-control study [to date] to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21543628\/\" target=\"_blank\" rel=\"noopener\">assess<\/a> the association between cholesterol intake and several types of cancer.\u201d The researchers found that \u201cdietary cholesterol intake was positively associated with risk of cancers of the stomach, colon, rectum, pancreas, lung, breast (mainly postmenopausal), kidney, bladder and NHL,\u201d non-Hodgkin\u2019s lymphoma, or bone marrow. The flipside? \u201cA diet low in cholesterol may play a role in the prevention of several cancers.\u201d This means cutting down on meat, dairy, and eggs, the very foods that may increase risk of cancer.<\/p>\n<p>\u201cThus, the findings of this study should essentially be viewed as an indication that a diet rich in meat, dairy products, eggs (and hence animal fat) is an unfavorable indicator of the risk of several common cancers\u2026\u201d Two cancers the study didn\u2019t investigate, though, were endometrial cancer and throat cancer. When all of the studies on cholesterol consumption and the risk of endometrial cancer (cancer of the lining of the uterus) were put together, researchers <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26959738\/\" target=\"_blank\" rel=\"noopener\">found<\/a> a dose-response, meaning more cholesterol consumption was associated with more cancer: 6 percent for every extra 100 mg of cholesterol each day. So, something like a daily omelet might increase endometrial cancer risk by about 20 percent. This may be because the extra cholesterol is converted into estrogen, or it may just be because the increased oxidative stress is reflected in higher levels of oxidized cholesterol. I talk about this in my video <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-as-a-cause-of-alzheimers-disease\/\" target=\"_blank\" rel=\"noopener\"><strong>Oxidized Cholesterol as a Cause of Alzheimer\u2019s Disease<\/strong><\/a>.<\/p>\n<p>There also <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25649888\" target=\"_blank\" rel=\"noopener\">appears<\/a> to be a dose-response relationship with pancreatic cancer, \u201cone of the most dismal malignancies.\u201d A compilation of studies found the risk of pancreatic cancer increased by 8 percent for every 100 mg of cholesterol, so that would be about a 30 percent higher risk for a daily omelet.<\/p>\n<p>And throat cancer? Increased risk was <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22968647\/\" target=\"_blank\" rel=\"noopener\">observed<\/a> by researchers for elevated cholesterol intake\u2014about 85 percent higher odds, which is consistent with other studies. Yes, maybe it\u2019s the oxidation, or maybe it\u2019s the inflammation. We can\u2019t, however, be sure the cholesterol itself is to blame. \u201cElevated cholesterol intake could be an indicator that a diet rich in meat, eggs, and dairy products may have unfavorable effects.\u201d<\/p>\n<p>The optimal intake of cholesterol? Zero. See <a href=\"https:\/\/nutritionfacts.org\/video\/trans-fat-saturated-fat-and-cholesterol-tolerable-upper-intake-of-zero\/\"><strong>Trans Fat, Saturated Fat, and Cholesterol: Tolerable Upper Intake of Zero<\/strong><\/a>.<\/p>\n<p><span class=\"et_social_bottom_trigger\"\/>  <\/div>\n<p><script>\n            !function(f,b,e,v,n,t,s)\n            {if(f.fbq)return;n=f.fbq=function(){n.callMethod?\n                n.callMethod.apply(n,arguments):n.queue.push(arguments)};\n            if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';\n            n.queue=[];t=b.createElement(e);t.async=!0;\n            t.src=v;s=b.getElementsByTagName(e)[0];\n            s.parentNode.insertBefore(t,s)}(window, document,'script',\n                'https:\/\/connect.facebook.net\/en_US\/fbevents.js');\n            fbq('init', '1582627921973608');\n            fbq('track', 'PageView');\n        <\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1675549\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is the relationship between the consumption of eggs and other cholesterol-rich foods and cancers of the colon, breast, endometrium, pancreas, and throat? In 1969, a correlation analysis was performed by a Dr. Gregor\u2014no relation, and he spelled it wrong\u2014and his colleagues. They found a rather tight correlation between animal protein intake and intestinal cancer &hellip;<\/p>\n","protected":false},"author":3,"featured_media":3596,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-3595","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/posts\/3595","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3595"}],"version-history":[{"count":0,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/posts\/3595\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=\/wp\/v2\/media\/3596"}],"wp:attachment":[{"href":"https:\/\/loudhdtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3595"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3595"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/loudhdtv.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3595"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}