{"id":3586,"date":"2023-05-11T13:44:36","date_gmt":"2023-05-11T06:44:36","guid":{"rendered":"https:\/\/loudhdtv.com\/can-oxidized-cholesterol-27hc-explain-three-breast-cancer-mysteries\/"},"modified":"2023-05-11T13:44:36","modified_gmt":"2023-05-11T06:44:36","slug":"can-oxidized-cholesterol-27hc-explain-three-breast-cancer-mysteries","status":"publish","type":"post","link":"https:\/\/loudhdtv.com\/?p=3586","title":{"rendered":"Can Oxidized Cholesterol 27HC Explain Three Breast Cancer Mysteries?"},"content":{"rendered":"<p> <script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js?client=ca-pub-3711241968723425\"\r\n     crossorigin=\"anonymous\"><\/script><br \/>\n<\/p>\n<div>\n<p>Oxidized cholesterol, which is concentrated in products containing eggs, processed meat, and parmesan cheese, has cancer-fueling estrogenic effects on human breast cancer.<\/p>\n<p>In 1908, the presence of cholesterol crystals was <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/path.1700130103\" target=\"_blank\" rel=\"noopener\">noted<\/a> \u201cin the proliferating areas of cancers,\u201d suggesting that cholesterol \u201cmay, in some way or other, be associated with the regulation of proliferation.\u201d A century later, we now <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25205720\/\" target=\"_blank\" rel=\"noopener\">recognize<\/a> that the \u201caccumulation of cholesterol is a general feature of cancer tissue, and recent evidence suggests that cholesterol plays critical roles in the progression of cancers, including breast, prostate, and colorectal cancers.\u201d I discuss this in my video <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries\/\" target=\"_blank\" rel=\"noopener\">Oxidized Cholesterol 27HC May Explain Three Breast Cancer Mysteries<\/a>.<\/p>\n<p>Might this <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24504557\/\" target=\"_blank\" rel=\"noopener\">explain<\/a> why egg consumption is associated with increased risk of breast cancer? Indeed, a systematic review and meta-analysis of the evidence \u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27333953\/\" target=\"_blank\" rel=\"noopener\">suggest<\/a> that dietary cholesterol intake increases risk of breast cancer,\u201d and the more cholesterol you eat, the higher the risk appears to rise, as you can see <span class=\"notion-enable-hover\" data-token-index=\"0\">in the graph below and <\/span>at 0:52 in my <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries\/\" target=\"_blank\" rel=\"noopener\"><strong>video<\/strong><\/a>. Why is that?<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-92282\" src=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52.png 1920w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-960x540.png 960w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-1024x576.png 1024w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-768x432.png 768w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-1536x864.png 1536w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-480x270.png 480w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-1200x675.png 1200w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-720x405.png 720w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/0-52-540x304.png 540w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\"\/><\/p>\n<p>One thought is the \u201cprolonged ingestion of a cholesterol-enriched diet <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26921636\/\" target=\"_blank\" rel=\"noopener\">induces<\/a> chronic, auto-inflammatory responses resulting in significant health problems including colorectal cancer,\u201d and we know that \u201cchronic nonresolving inflammation leads to the initiation, promotion, and progression of tumor development.\u201d As you can see <span class=\"notion-enable-hover\" data-token-index=\"0\">in the graph below and <\/span>at 1:12 in my <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries\/\" target=\"_blank\" rel=\"noopener\"><strong>video<\/strong><\/a>, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26921636\/\" target=\"_blank\" rel=\"noopener\">sprinkling<\/a> some cholesterol on white blood cells in a test tube can trigger the release of inflammatory compounds, and LDL cholesterol can <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24428917\/\" target=\"_blank\" rel=\"noopener\">induce<\/a> breast cancer proliferation and invasion, but that\u2019s in vitro. In a petri dish, you can show that breast cancer cells can migrate nearly twice as far within a day in the presence of LDL cholesterol, but what happens in people?<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-92280\" src=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12.png 1920w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-960x540.png 960w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-1024x576.png 1024w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-768x432.png 768w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-1536x864.png 1536w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-480x270.png 480w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-1200x675.png 1200w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-720x405.png 720w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/1-12-540x304.png 540w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\"\/><\/p>\n<p>The level of LDL cholesterol in the blood of women <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24571647\/\" target=\"_blank\" rel=\"noopener\">diagnosed<\/a> with breast cancer does appear to be a predictive factor of tumor progression. About two years after surgery, chemotherapy, and radiation, not a single one of the women in the lowest third of LDL cholesterol levels had a cancer recurrence. The same could not be said for women with higher cholesterol. We know cholesterol can cause inflammation in our artery walls. Might it also have an effect on breast cancer initiation and progression? Researchers speculate that high cholesterol levels may have a \u201ccancer-fuelling effect,\u201d and, indeed, women with breast cancer who happen to be <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27853392\/\" target=\"_blank\" rel=\"noopener\">taking<\/a> cholesterol-lowering statin drugs appear to live about 40 percent longer before the cancer comes back. The data aren\u2019t good enough to ensure the drug benefits outweigh their risks, though. Lowering cholesterol with diet may be able to give us the best of both worlds.<\/p>\n<p>Animal studies <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27197250\/\" target=\"_blank\" rel=\"noopener\">show<\/a> that if you feed cholesterol to mice, you can accelerate their cancers, \u201cbut extrapolation to humans is difficult as dietary cholesterol has limited effect on blood cholesterol levels in humans.\u201d Thus, dietary cholesterol might just be \u201cindicative of a lifestyle prone to health-related problems, including cancer\u201d\u2014that is, maybe people are just more likely to have an after-meal cigarette if that meal is bacon and eggs compared to oatmeal. It was difficult to imagine how dietary cholesterol alone could promote cancer development, but that changed recently with the discovery that 27-hydroxycholesterol, \u201c27HC, a metabolite of cholesterol, can <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27333953\" target=\"_blank\" rel=\"noopener\">function<\/a> as an estrogen and increase the proliferation of estrogen receptor-positive breast cancer cells.\u201d<\/p>\n<p>So, it\u2019s not the cholesterol itself, but what the cholesterol <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25458418\/\" target=\"_blank\" rel=\"noopener\">turns<\/a> into inside our body.<strong> \u201c<\/strong>Scientists have long struggled to <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24712111\/\">understand<\/a> why women with heart disease risk factors are more likely to develop breast cancer.\u201d Now, perhaps, we know. \u201cThe discovery that the most abundant cholesterol oxidized metabolite in the plasma,\u201d in our bloodstream, can have estrogenic effects may <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28583434\/\" target=\"_blank\" rel=\"noopener\">explain<\/a> the link between high cholesterol and the development and progression of breast cancer and prostate cancer. And, 27-hydroxycholesterol also <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28503095\/\" target=\"_blank\" rel=\"noopener\">stimulates<\/a> the proliferation of prostate cancer cells, boosting growth by about 50 percent, as you can see <span class=\"notion-enable-hover\" data-token-index=\"0\">in the graph below and <\/span>at 3:58 in my <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries\/\"><strong>video<\/strong><\/a>.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-92285\" src=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58.png 1920w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-960x540.png 960w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-1024x576.png 1024w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-768x432.png 768w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-1536x864.png 1536w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-480x270.png 480w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-1200x675.png 1200w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-720x405.png 720w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/3-58-540x304.png 540w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\"\/><\/p>\n<p>I\u2019ve previously explored the \u201crole for oxysterols in <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21388551\/\" target=\"_blank\" rel=\"noopener\">mediating<\/a> pro-oxidative and pro-inflammatory processes in age-related degenerative diseases such as Alzheimer\u2019s disease and atherosclerosis,\u201d heart disease, but it now looks like oxidized cholesterol can play a role in all three stages of tumor development, as well: initiation, promotion, and then the progression of the cancer, as you can see below and at 4:14 in my <a href=\"https:\/\/nutritionfacts.org\/video\/oxidized-cholesterol-27hc-may-explain-3-breast-cancer-mysteries\/\" target=\"_blank\" rel=\"noopener\"><strong>video<\/strong><\/a>. It doesn\u2019t just promote the growth of breast cancer cells, but also \u201c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28257824\/\" target=\"_blank\" rel=\"noopener\">induces<\/a> invasion and migration of breast cancer cells,\u201d potentially <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29021522\/\" target=\"_blank\" rel=\"noopener\">facilitating<\/a> breast cancer metastasis through suppressing anti-cancer immunity and then <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27856279\/\" target=\"_blank\" rel=\"noopener\">inducing<\/a> angiogenesis, helping breast tumors hook up their blood supply.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-92287\" src=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14.png\" alt=\"\" width=\"1920\" height=\"1080\" srcset=\"https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14.png 1920w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-960x540.png 960w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-1024x576.png 1024w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-768x432.png 768w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-1536x864.png 1536w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-480x270.png 480w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-1200x675.png 1200w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-720x405.png 720w, https:\/\/nutritionfacts.org\/app\/uploads\/2023\/04\/4-14-540x304.png 540w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\"\/><\/p>\n<p>\u201cSeveral lines of evidence <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28919300\/\" target=\"_blank\" rel=\"noopener\">support<\/a> a pathologic role\u201d for this cholesterol metabolite. We know that when you feed cholesterol to mice, their oxysterol levels <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26959708\" target=\"_blank\" rel=\"noopener\">go<\/a> up and their tumors accelerate, but it \u201calso appears to dramatically <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24288308\" target=\"_blank\" rel=\"noopener\">hasten<\/a> the spread, or metastasis, of breast tumors to other organs.\u201d But, when researchers \u201cturned to human breast tissue samples, they found that more aggressive tumors had higher levels of an enzyme\u2026which converts cholesterol into 27HC.\u201d In breast cancer patients with estrogen receptor-positive tumors, the 27-hydroxycholesterol content in their breast tissue is <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24210818\/\" target=\"_blank\" rel=\"noopener\">increased<\/a> overall and especially within the tumor itself\u2014so much so that circulating oxysterol levels in the blood may one day be <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27343991\/\" target=\"_blank\" rel=\"noopener\">used<\/a> as a prognostic factor. And \u201cbreast cancer patients with low tumor levels of\u2026[the] enzyme that breaks down 27HC\u2026did not <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24288308\/\" target=\"_blank\" rel=\"noopener\">live<\/a> as long as women with the highest levels\u201d who can detoxify it better. \u201cThe bottom line\u2026is that some estrogen-driven breast tumors may rely on 27HC to grow when estrogen isn\u2019t available.\u201d And that may explain a <em>second<\/em> breast cancer mystery.<\/p>\n<p>More than 80 percent of breast cancers <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27246191\/\" target=\"_blank\" rel=\"noopener\">start<\/a> out responding to estrogen, so we use hormone blockers\u2014either aromatase inhibitors to stop the formation of estrogen in the first place or the drug tamoxifen to block its action. Despite the efficacy of these drugs, many patients relapse with resistant tumors, and that\u2019s where oxidized cholesterol can come in. 27HC can <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24288308\/\" target=\"_blank\" rel=\"noopener\">fuel<\/a> breast cancer growth without estrogen, which could explain why these estrogen blockers sometimes don\u2019t work.<\/p>\n<p>And, finally, 27HC may <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28589744\/\" target=\"_blank\" rel=\"noopener\">explain<\/a> why breast cancer patients with higher vitamin D levels appear to live longer. Vitamin D supplementation <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29116467\/\" target=\"_blank\" rel=\"noopener\">decreases<\/a> 27HC levels in the blood.<\/p>\n<p>The best way to reduce our risk of getting breast cancer\u2014and surviving it if we do get the diagnosis\u2014may be to just <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28442559\/\" target=\"_blank\" rel=\"noopener\">lower<\/a> our overall cholesterol. If you lower your cholesterol, you lower your oxidized cholesterol. So, <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27020054\/\" target=\"_blank\" rel=\"noopener\">discovering<\/a> this role of cholesterol is actually really good news, since \u201ccholesterol is a highly amenable risk factor, either by lifestyle, dietary, or pharmacologic interventions.\u201d One of the implications of these findings, according to the principal investigator, is that \u201clowering cholesterol with dietary changes or statins [drugs] could reduce a women\u2019s breast cancer risk or slow tumor growth.\u201d<\/p>\n<p>Since vitamin D supplementation decreases 27-HC levels in the blood, you may be interested in the best way get Vitamin D. See my videos <a href=\"https:\/\/nutritionfacts.org\/video\/the-best-way-to-get-vitamin-d-sun-supplements-or-salons\/\" target=\"_blank\" rel=\"noopener\">The Best Way to Get Vitamin D: Sun, Supplements, or Salons?<\/a> and <a href=\"https:\/\/nutritionfacts.org\/video\/the-risks-and-benefits-of-sensible-sun-exposure\/\" target=\"_blank\" rel=\"noopener\">The Risks and Benefits of Sensible Sun Exposure<\/a>.<\/p>\n<p><span class=\"et_social_bottom_trigger\"\/>  <\/div>\n<p><script>\n            !function(f,b,e,v,n,t,s)\n            {if(f.fbq)return;n=f.fbq=function(){n.callMethod?\n                n.callMethod.apply(n,arguments):n.queue.push(arguments)};\n            if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';\n            n.queue=[];t=b.createElement(e);t.async=!0;\n            t.src=v;s=b.getElementsByTagName(e)[0];\n            s.parentNode.insertBefore(t,s)}(window, document,'script',\n                'https:\/\/connect.facebook.net\/en_US\/fbevents.js');\n            fbq('init', '1582627921973608');\n            fbq('track', 'PageView');\n        <\/script><br \/>\n<br \/><div data-type=\"_mgwidget\" data-widget-id=\"1675549\">\r\n<\/div>\r\n<script>(function(w,q){w[q]=w[q]||[];w[q].push([\"_mgc.load\"])})(window,\"_mgq\");\r\n<\/script>\r\n<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oxidized cholesterol, which is concentrated in products containing eggs, processed meat, and parmesan cheese, has cancer-fueling estrogenic effects on human breast cancer. In 1908, the presence of cholesterol crystals was noted \u201cin the proliferating areas of cancers,\u201d suggesting that cholesterol \u201cmay, in some way or other, be associated with the regulation of proliferation.\u201d A century &hellip;<\/p>\n","protected":false},"author":3,"featured_media":3587,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"class_list":["post-3586","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"Oxidized cholesterol, which is concentrated in products containing eggs, processed meat, and parmesan cheese, has cancer-fueling estrogenic effects on human breast cancer. 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